ASC is a TLA that may stand for:
- Accounting Standards Committee
- Accredited Standards Committee (ANSI)
- Actuarial Systems Corporation
- Adelaide Sailing Club
- Adhesive and Sealant Council
- Advanced Switching Communications (asc.com)
- Advanced Strategic Command (game)
- Aero Sports Connection
- African Safari Club
- Agnes Scott College
- Alabama Supercomputer Center
- Alternative System Concepts
- Amateur Seismic Centre
- American Society of Cinematographers
- American Society for Composites
- American Society of Criminology
- American Society for Cybernetics
- American Society of Cytopathology
- American Solar Challenge
- American Southwest Conference
- American Spaniel Club
- American Standard Circuits
- Analytic Surface Calculation
- Annenberg School for Communication
- Anglo-Saxon Chronicle
- Army Signal Command
- Asperger Syndrome Coalition
- Associated Schools of Construction
- Association of Scottish Colleges
- Association of Speakers Clubs
- Association for Survey Computing
- Astrophysics Simulation Collaboratory
- Atlanta Sacred Chorale
- Atlanta Soaring Club
- Atlanta Sports Council
- Australian Science Communicators
- Australian Sports Commission