DeSoto is the name of several places in the United States of America:
- DeSoto, Georgia
- DeSoto, Indiana
- DeSoto, Missouri
- DeSoto, Texas
- DeSoto, Wisconsin (two places):
- in Crawford County
- in Vernon County
- DeSoto County, Florida
- DeSoto County, Mississippi
This is a disambiguation page; that is, one that just points to other pages that might otherwise have the same name. If you followed a link here, you might want to go back and fix that link to point to the appropriate specific page.