- Medusa was a gorgon from Greek mythology whose gaze turned people to stone.
- Medusae are a form of coelenterate in which the body is shortened on its principal axis and broadened, sometimes greatly, in contrast with the hydroid or polyp.
- Medusa a fictional superhero in the Marvel Universe
- Medusa is a proposed type of nuclear pulse propulsion using a solar sail as its "pusher plate"
- Medusa is board game that is based on a variant of go. Medusa is purported invented by Mark Berger in 1975. ( http://www.mindsports.net/Arena/CompleteGames/Territory/Medusa.html )