Centuries: 14th century - 15th century - 16th century
- Yoshitane becomes Ashikaga shogun of Japan.
- Charles John Amadeus of Savoy becomes Duke of Savoy at age 1, mother Blanche of Montferrato is regent.
- Aldus Manutius moves to Venice.
- John Colet receives M.A. from Magdalen College, Oxford.
- Castle Church in Wittenberg is begun.
- Pedro de Covilham arrives in Ethiopia.
- Catholic missionaries arrive in the African kingdom of Kongo.
- March 24 - Georg Agricola, German scholar, scientist (+ 1555)
- May 16 - Albert, Duke of Prussia (+ 1568)
- June 28 - Albert of Mainz, elector, archbishop
- Vittoria Colonna, Italian poetess (+ 1547)
- Jean Salmon Macri, poet (+ 1557)
- Andrej Perlah, Slovene mathematician
- Philip, Duke of Nemours, son of Philip II of Savoy
- Bernhard von Reesen Gdansk merchant (approximate date)
- Kaspar Schwenkfeld von Ossig, German theologian (+ 1561)