Centuries: 2nd century - 3rd century - 4th century
- Valerian I captured by the Persian king Shapur I; Gallienus becomes sole Roman emperor.
- Shapur destroys Caesarea Mazaca in Asia Minor.
- Cao Huan succeeds Cao Mao as ruler of the Chinese Kingdom of Wei.
- Syria, Egypt and Palestine break off from the Roman Empire to form the Persia-supported Palmyran Empire.
- Roman fort of Wiesbaden (Germany) captured by the Alamanni (possibly 259).
- Franks took control over the Scheldt estuary (approximate date).
- Earliest known date of chess.
- Paul of Samosata becomes Patriarch of Antioch.
- Emperor Hui of Jin China (approximate date)