Centuries: 4th century BC - 3rd century BC - 2nd century BC
- Antiochus II Theos succeeds Antiochus I Soter.
- The Chremonidean War ends.
- First Punic War: Appius Claudius Caudex leads Roman troops into Sicily
- Beginning of the year, Battle of Agrigentum: Carthaginian forces under Hannibal Gisco and Hanno are defeated by the Romans, giving them control of most of Sicily
- Antiochus I Soter (dies in battle)