Centuries: 5th century BC - 4th century BC - 3rd century BC
- Macedonia's port city, Thessalonica, is founded in honor of Thessaloniki, daughter of Philip II of Macedon and sister of King Philip III of Macedon.
- Battle of Ciuna, the Romans defeat the Samnites.
- Agathocles, the tyrant of Syracuse, seizes the city of Messina
- City of Thebes restored by Cassander
- Aratus, Macedonian Greek mathematician, astronomer, meteorologist, botanist and poet (possibly born in 310 BC)