Centuries: 5th century BC - 4th century BC - 3rd century BC
- Aristotle, a student of Plato, investigates natural history (especially marine biology) on the island of Lesbos.
- Plato moves from Assus to Mitylene.
- Eastern Anatolia separates from Persia.
- Dionysius, Tyrant of Syracuse goes into exile after an invasion by Timoleon of Corinth.
- Battle of Granciu.
- Larissa Thessaly