AFB is a TLA that may stand for:
- Absolute fairness bound
- Acid-fast bacilli
- Air Force base
- Akademie für Bioenergetik (afb.li)
- American Farm Bureau
- American foulbrood (honeybee disease)
- American Foundation for the Blind (afb.org)
- Amt für Berufsbildung (Lucerne)
- Anaerobic fluidized bed
- Anti-friction bearing
- Arbeitsstelle Friedensforschung Bonn
- Assault Float Bridge (US Army)
- Association for Biometrics (afb.org.uk)
- Association Française des Banques (afb.fr)
- Atmospheric fluidized bed
- SIL code for spoken Gulf Arabic