In public health, a big killer is a disease or other major cause of loss of human life. Examples include:


Ten Leading Causes of Death in the United States in the year 2000:

  1. Heart disease: 710,760
  2. Cancer: 553,091
  3. Stroke: 167661
  4. Chronic lower respiratory disease: 122,009
  5. Accidents: 97,900
  6. Diabetes: 69,301
  7. Pneumonia/Influenza: 65,313
  8. Alzheimer's disease: 49,558
  9. Nephritis, nephrotic syndrome, and nephrosis: 37,251
  10. Septicemia: 31,224

Source: National Vital Statistics Report, Vol. 50, No. 16, courtesy of United States National Center for Health Statistics