Chimera can mean the following:
- A creature in the Greek Mythology; see Chimera (creature)
- Single animal organisms with genetically distinct cells from two different zygotes; see Chimera (animal)
- Single plant organisms with genetically distinct cells; see Chimera (plant)
- Hybrid proteins made by the splicing of two genes; see Chimera (protein)
- A group of cartilaginous fishes; see Chimera (fish)
- Chimera is the older name of a web browser; see Camino.
- A model of sports car made by TVR; see Chimera (car)
- A 1972 novel by John Barth; see Chimera (novel)