Clayton is the name of some places in the United States of America:
- Clayton, Alabama
- Clayton, California
- Clayton, Connecticut
- Clayton, Delaware
- Clayton, Georgia
- Clayton, Idaho
- Clayton, Illinois
- Clayton, Indiana
- Clayton, Iowa
- Clayton, Kansas
- Clayton, Louisiana
- Clayton, Maryland
- Clayton, Massachusetts
- Clayton, Michigan
- Clayton, Mississippi
- Clayton, Missouri
- Clayton, New Jersey
- Clayton, New Mexico
- Clayton, New York
- Clayton, North Carolina
- Clayton, Ohio
- Clayton, Oklahoma
- Clayton, Pennsylvania
- Clayton, South Carolina
- Clayton, South Dakota
- Clayton, Tennessee
- Clayton, Texas
- Clayton, Washington
- Clayton, West Virginia
- Clayton, Wisconsin
- Clayton, Wyoming