CMS can stand for:
- Changeable Message Sign
- The Chicago Manual of Style, a guide to American English publication style
- The Compact Muon Solenoid detector, a particle physics experiment being built on the Large Hadron Collider accelerator at CERN.
- Content management system - a software used to organize and facilitate collaborative content creation
- Conversational Monitor System, an IBM operating system that runs primarily on mainframe computers
- Code Management System, a software package for performing source code management on computers running the OpenVMS operating system
- Code Morphing Software, a software package for the Crusoe microprocessor which emulates x86-compatible virtual machine
- The Centers for Medicare and Medicaid Services