Custer's Revenge was a adult-oriented video game made for the Atari 2600 by Mystique, a company that produced a number of X-rated, pornographic video games. It was one of several video game companies that tried to use sex to sell its games.

According to industry watchers and critics, Mystique's games were generally simple, with crude graphics and unexceptional gameplay. However, Custer's Revenge gained notoriety for its particular game design. In the game, the player controls the character of "Custer," a naked man in a cowboy hat. Custer has to overcome various (not very difficult) obstacles to achieve the his goal and win the game, by having sex with a crudely depicted, large-breasted American Indian woman who is tied to a stake.

The game's design prompted complaints and public statements from various spokespersons for women's rights groups (who felt that the image of having sex with a tied-up woman was a simulation of rape), conservative anti-pornography actvists, American Indian spokespersons, and critics of the video game industry in general.

Custer's Revenge is generally seen by video game collectors and historians as the single worst home video game ever made.

Like many other video game manufacturers, Mystique went out of business in the wake of the video game crash of 1983.