Diff'rent Strokes is the name of an American sitcom in that aired from 1978 to 1986 on NBC.

The sitcom was about two African-American children in New York City who were adopted by a rich white widower who had a daughter and a maid. The cast members included Todd Bridges, Gary Coleman, Dana Plato, and Conrad Bain. The child stars ended up having problems after the show ended. Plato died due to a drug overdose, while Coleman and Bridges got into legal trouble.

Diff'rent Strokes was the source of the spinoff series The Facts of Life.