Doolittle refers to a number of people and things:
- Doolittle is The Pixies' second full-length album, released in March 1989.
- Eliza Doolittle, a fictional young street vendor of flowers, is the title character of the play Pygmalion and of the musical comedy My Fair Lady (and several films versions of each of them); her father, Alfred Doolittle, a navvy (or unskilled laborer), is also a character in these.
- General Jimmy Doolittle (James Harold Doolittle) commanded (as a colonel) the 1942 Doolittle Raid, bombing Tokyo less than five months after the Attack on Pearl Harbor that marked the United States' official entrance into World War II. Though it caused only minor damage, it was a significant morale boost for the USA and a psychological blow to the heretofore secure Japanese.
- Doctor Dolittle is a character in a series of books by Hugh Lofting, and the title character of two movies, the most recent starring Eddie Murphy, based on this character.
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