Enterprise can refer to any of the following:
- A business or organization
- The USS Enterprise, one of several ships of the United States Navy
- A privately owned steamboat captained by Henry Miller Shreve, see Enterprise (steamboat)
- The Space Shuttle Enterprise
- A television show in the Star Trek franchise, see Enterprise (series)
- One of a number of fictional spacecraft from the Star Trek series of television shows, see Starship Enterprise
- A community in Northwest Territories, Canada. (Postal Code X0E 0R1)
- An 8 bit homecomputer from the UK (Enterprise 64) Also known as Flan and Elan