Estes Kefauver (July 26, 1903 - August 10, 1963) was an American politican from Tennessee.

Kefauver was born in Madisonville, Tennessee and attended the University of Tennessee and Yale University. He was a member of the United States House of Representatives from 1939 to 1949. He served in the United States Senate from 1949 to his death in 1963. He led a U.S. Senate committee investigating organized crime in 1950, that brought him national attention. He was the Democratic Party Vice Presidental nominee in 1956.

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