Francis Lewis (March, 1713 - December 31, 1802), was a signer of the United States Declaration of Independence as a representative of New York.

Born in Wales, he was educated in Scotland and attended Westminster in England. He entered a mercantile house in London, then moved to New York in 1734. He was taken prisoner and shipped to France while serving as a British mercantile agent in 1756. On his return to America, he became active in politics, and was elected to the Continental Congress in 1775. His property on Long Island, New York was destroyed in the Revolutionary War.