Karl Ludwig Nitzsch (1751-1831) was a German theologian.

Like his son, the better-known Karl Immanuel Nitzsch, he earned some distinction in the theological world by a number of writings, including a work entitled De discrimine revelationis imperaboriae et didacticae prolusiones academicae (2 vols., 1830). Theologically, he represented a combination of supernaturalism and rationalism (supernatural rationalism or a Kantian rational supernaturalism).