Manduessedum was a Roman fort settlement in modern day Warwickshire in England.

The fort was founded in around c AD 50-AD 60 on the Watling Street Roman road. The final battle between the rebel queen of the Britons Boudicca may have taken place near Manduessedum. The British forces were defeated by the Roman general Suetonius Paullinus.

The modern town of Atherstone is built close to the site of Manduessedum.