For towns of this name, see Manlius, Illinois, Manlius Township, Michigan, and Manlius, New York.

Manlius (fem. Manlia) was the nomen of the gens Manlia, a patrician family of ancient Rome, one of the oldest of the city.

Cognomina of the Manlii included Acidinus, Capitolinus, Imperiosus, Torquatus, and Vulso.