In the USA, on June 26, 2000 the White House Millennium Council selected 16 long-distance trails from 58 nominees for designation as National Millennium Trails, chosen as visionary trails that reflect defining aspects America's history and culture.
First Lady Hillary Rodham Clinton said: "Through the Millennium Trails project, we are building and maintaining trails that tell the story of our nation's past and will help to create a positive vision for our future. The 16 National Millennium Trails that Secretary Slater designated today are all visionary projects that define us as Americans."
- Unicoi Turnpike - 68.8 miles - from Murphy, North Carolina westward to Vonore, Tennessee exploring the Cherokee Trail of Tears
- Cascadia Marine Trail - 160 miles - from Olympia, Washington to Point Roberts, Washington at the Canadian border tracing early Native American trade routes in the Puget Sound region.
- Juan Bautista de Anza National Historic Trail - 1,200 miles - from Nogales, Arizona northwestward to San Francisco, California marks the route of Spain's exploration and settlement led by Juan Bautista de Anza
- Freedom Trail - 2.5 miles - from Boston Commons to Bunker Hill Monument in Boston, Massachusetts connecting 15 sites of great significance in the Colonial history of the United States.
- Lewis and Clark National Historic Trail - 3,700 miles - from Camp DuBois at Wood River, Illinois westward to Les Shirley Park, Oregon commemorating the Lewis and Clark Expedition of 1804 to 1806.
- Underground Railroad Trail - various routes through the Eastern United States, Texas, Oklahoma, southern Canada, Mexico and the Caribbean representing the Underground Railroad escape routes for people held in slavery prior to the American Civil War.
- Civil War Discovery Trail - 500 sites in 27 states - honors the sacrifices and hardships of the American Civil War.
- International Express Trail - 5 miles - Queens County, New York from Sunnyside to Flushing follows the route of New York City's Number Seven subway line which was built to redistribute the large numbers of recent immigrants in the early 1900s.
- Iditarod National Historic Trail - 938 miles - Seward, Alaska northwestward to Nome, Alaska traces America's only remaining frontier trail, the route of the Iditarod dogsled race and the human migratory route across the Bering Land Bridge.
- Appalachian National Scenic Trail - 2160 miles - Springer Mountain, Georgia to Mt. Katahdin, Maine this forested trail is the longest natural public thoroughfare in the world
- Great Western Trail - 3,100 miles - Canadian border southward to the Mexican border through Montana, Idaho, Wyoming, Utah and Arizona
- North Country National Scenic Trail - 4,600 miles - from Lake Sakakawea, North Dakota eastward to Port Henry, New York traversing the different types of landscapes that define the northern rim of the continental United States.
- Hatfield-McCoy Trail System - 2,000 miles through West Virginia, Kentucky and Virginia along the mountain ridges and abandoned coal mining fields of southern West Virginia
- East Coast Greenway - 2,500 miles - Key West, Florida northward to Calais, Maine connecting 15 of America's most populous states and most major cities on the eastern seaboard.
- Mississippi River Trail - 2,000 miles - from Lake Itasca, Minnesota southward to New Orleans, Louisiana honors one of the world's longest rivers.
- American Discovery Trail - 6,356 miles from Cape Henlopen State Park, Delaware westward to Point Reyes National Seashore, California