OCS is a TLA that may stand for:
- Carbonyl sulfide
- Obsessive-compulsive scale
- Obsessive-compulsive symptoms
- Ocean Color Scene
- Office of Career Services (several)
- Office of the Chief Scientist (Australia)
- Office of Coast Survey (NOAA)
- Office coffee service
- Office of Community Services
- Office of Cyberspace Security (US)
- Officer Cadet School (several military)
- Officer Candidate School (several military)
- Offshore Constitutional Settlement (Australia)
- Oklahoma Climatological Survey
- Old Church Slavonic
- Onboard computer system
- Open Channel Solutions Inc. (ocs.com)
- Open Content Syndication
- Operations control software
- Operational Control Segment (GPS)
- Operational control system (avionics)
- Operator control station
- Optical Calibration Sphere
- Optical control system
- Optical convergence switch
- Oregon Climate Service
- Original chipset or "old chipset" (Amiga)
- Ouachita Christian School (ocs.org)
- Outer continental shelf
- OCS Canada ("Overseas Courier Service", ocs.ca)