OMC is a TLA that may stand for:
- Offshore Management Centre
- Offshore Marine Contractors, Inc.
- Offshore Mediterranean Conference
- Oman Medical College
- online map creation
- Ontario Multifaith Council
- Open Management Console
- Open Medical Club
- Open Method of Coordination
- open mitral commissurotomy
- Operations and Maintenance Center
- Operations Management Center
- optical media converter
- optical memory card
- Optical Metrology Centre
- optical microcavity
- optical mode conditioner
- Optical Monitoring Camera
- Organisation mondiale du commerce (French for World Trade Organization)
- Osaka Medical College
- Osceloa Medical Center
- Otara Millionaires Club
- Ozarks Medical Center
