Simplicius was pope from 468 to 483. He was born at Tivoli, Italy, the son of a citizen named Castinus.

Simplicius defended the action of the Council of Chalcedon against the Monophysite heresy, labored to help the people of Italy against the marauding raids of barbarian invaders, and saw the Heruli mercenaries revolt and proclaim Odoacer king in 476.

Preceded by:
Pope Hilarius
List of popes Succeeded by:
Pope Felix III