Poughkeepsie is a city in New York's Hudson Valley. It is the county seat of Dutchess County, New York, and is best known as the location of Vassar College.

Poughkeepsie was founded in 1867 and has a current population (as of 2003) of approximately 30,000 people. The city name is believed to be derived from a Native American word, but the meaning is unknown.

The city of Poughkeepsie is bordered by the Hudson River and, on the other three sides, by a town also called "Poughkeepsie".

It is home to Vassar College, one of the Seven Sisters schools.