- Pythons are constricting snakes belonging to the family Pythonidae.
- Python, (comp.sc), is an interpreted, interactive, object-oriented programming language, designed by Guido van Rossum and named after Monty Python's Flying Circus.
- Monty Python was a British comedy troupe, known for Monty Python's Flying Circus and several movies.
- In Greek mythology, Python was a vicious dragon, a child of Gaia, that lived near Delphi and was killed by Apollo.
- Python is a 2000 horror movie by Richard Clabaugh.