Reed-Sternberg cells are malformed cells found in individuals with Hodgkin's disease (a type of lymphoma), and certain other disorders.

They are named after Dorothy Reed (1874-1964) and Carl von Sternberg or George M. Sternberg (1838-1915); there is conflicting data on which is the correct Sternberg. These large cells have two nuclei, among other features. Although the presence of these cells is necessary for the diagnosis of Hodgkin's lymphoma, the cells are found in other disorders as well (such as mononucleosis, caused by the ever-more mysterious Epstein-Barr virus, which is also implicated in Burkitt's lymphoma).