Regeneration is a 1915 film which tells the story of a poor orphan who rises to control the mob, until he meets a woman for whom he wants to change. It stars John McCann, James A. Marcus , Maggie Weston, H. McCoy, Rockliffe Fellowes, William Sheer, Carl Harbaugh and Anna Q. Nilsson.

It was adapted by Carl Harbaugh and Raoul Walsh from a memoir My Mamie Rose by Owen Frawley Kildare and the adapted play by Kildare and Walter C. Hackett. It was directed by Walsh. In 2000 the United States Library of Congress deemed the film "culturally significant" and selected it for preservation in the National Film Registry.