Published in 1945, Stuart Little became E.B. White's first children's story. It's the tale of a young boy named Stuart Little who looks like a mouse and is no more than a couple inches tall. Stuart is good natured and goes through many adventures while living with his family in New York City. Eventually, he sets out on a journey to find his friend Margalo, a bird saved by Stuart's family. According to White, the idea for this story came in a dream while he was sleeping on train.

The story was adapted into a film, also called Stuart Little, in 1999. Its popularity ensured a sequel, Stuart Little 2, in 2002. The films are live-action, with a computer-animated Stuart voiced by Michael J. Fox, although some have claimed that the films' most remarkable special effect is British actor Hugh Laurie's convincing American accent.