Tenderloin was the neighborhood of the West Side of Manhattan between W. 14th Street and W. 57th Street, from the mid 1800s to the 1920s. It was primarily an African-American neighborhood. With the construction of Penn Station, and new, cheaper housing in Harlem, much of the Tenderloin's Black community moved uptown by 1920.

It became an industrial area, but since the 1970s, with gentrification, the old Tenderloin's Chelsea, Hells Kitchen, and Clinton sections became increasingly residential again.