The Two Guys from Andromeda were the authors of the Space Quest series, perhaps the greatest humourous space Adventure games this side of Xenon. The two guys consist of Mark Crowe (who did most of the music and visual art in the early games) and Scott Murphy (who was the programmer and the beard-bearing member of the two). Josh Mandel was the third second guy from Andromeda, who did most of the work on Space Quest 6. There were also rumours of a self-proclaimed Gal from Andromeda, Leslie Balfour (aka. Apollonia Jones).

The Space Quest games were published by Sierra Online in the late 1980s and early 1990s, and used the same house game engine developed earlier for King's Quest.