Several people have been known by the name William Hamilton.
- William Hamilton (14th century), Dean of York and Lord Chancellor 1305-1307: see William Hamilton (Lord Chancellor)
- William Hamilton (1665-1751), Scottish poet: see William Hamilton of Gilbertfield
- William Hamilton (1704-1754), Scottish poet: see William Hamilton (Jacobite poet)
- Sir William Hamilton (1730-1803), Scottish diplomat and husband of Emma Hamilton: see William Hamilton (diplomat)
- Sir William Hamilton, Bt. (1788 - 1856), the Scottish metaphysician: see William Hamilton (metaphysician)
- William Rowan Hamilton (1805 - 1865), the Irish mathematician: see William Rowan Hamilton
- William T. Hamilton, Governor of Maryland (1880-1884)
- William Hamilton, tennis player, winner of the 1890 Wimbledon championships, see William Hamilton (tennis player)
- William Hamilton, anti-monarchist MP: see Willie Hamilton