Centuries: 15th century - 16th century - 17th century
- February 11 - Battle of Wayna Daga - Ethiopian/Portuguese? troops beat Muslim army.
- May - Nicolaus Copernicus publishes De revolutionibus orbium coelestium
- July 12 - King Henry VIII of England marries Catherine Parr.It is the sixth of Henry's marriages and the third of Catherine's.
- Nice is captured and sacked by a Franco-Turkish fleet under Khair ed-Din Barbarossa.
- September-October - Landrecies in Picardy is besieged by forces under Emperor Charles V, but withdraw on the approach of the French army.
- Andreas Vesalius publishes 'De Humani Corporis Fabrica' (On the Fabric of the Human Body), revolutionising the science of human anatomy
- Tokugawa Ieyasu, Japanese shogun
- Sonam Gyrso, who will become Tibet's 3rd Dalai Lama Buddhism
- Federigo Zuccaro, Italian painter