The De Soto was a brand of automobile based in the United States of America, marketed by the Chrysler Corporation from 1928 through 1960.

The De Soto make was founded by Walter P. Chrysler on August 4, 1928. It was named after the Spanish explorer Hernando de Soto. Chrysler wanted to enter the brand in the competition with the arch rivals Oldsmobile, Nash and Pontiac. Intially, this was quite a success. But because the make was often fitted with the same body work as the Plymouth and Dodge, it lost its individual character.

The production of De Sotos ceased on November 30, 1960.

List of automobiles