Trinidad and Tobago maintains close relations with its Caribbean neighbors and major North American and European trading partners. As the most industrialized and second-largest country in the English-speaking Caribbean, Trinidad and Tobago has taken a leading role in the Caribbean Community and Common Market (CARICOM), and strongly supports CARICOM economic integration efforts. It also is active in the U.S.-initiated Summit of the Americas process and fully supports the establishment of the Free Trade Area of the Americas, lobbying other nations for seating the Secretariat in Port of Spain.

As a member of CARICOM, Trinidad and Tobago strongly backed efforts by the United States to bring political stability to Haiti, contributing personnel to the Multinational Force in 1994. After its 1962 independence, Trinidad and Tobago joined the UN and the Commonwealth. In 1967, it became the first Commonwealth country to join the Organization of American States (OAS). In 1995, Trinidad played host to the inaugural meeting of the Association of Caribbean States and has become the seat of this 35-member grouping, which seeks to further economic progress and integration among its states. In international forums, Trinidad and Tobago generally supports U.S. and EU positions, while guarding an independent voting record.

Trinidad and Tobago is a transshipment point for South American drugs destined for the United States and Europe. The islands are also a producer of cannabis, leading to some tension with foreign nations.