- Roberto Clemente, (1934 - 1972), baseball player
- José Feliciano, (born 1945), Latin and Rock singer
- Raúl Juliá, (1944 - 1994), actor
- Luis Muñoz Marín, (1898-1980), four term governor of Puerto Rico
- Tito Puente, (1943 - 2000), Latin jazz and salsa musician
- Luis Rafael Sánchez, (born 1936), essayist, playwright, and novelist
- Lola Rodríguez de Tío, (1843-1924), poet
- Alejandro Tapía y Rivera, (1826-1882), playwright and journalist
- Manuel Zeno Gandía, (1885 - 1930), novelist