Luca Signorelli (c.1445-1523), Umbrian painter, is noted for his ability as a draughtsman and his use of foreshortening. His work shows his interest in anatomy.

His masterpiece is considered to be his fresco of the Last Judgment (1499) in Orvieto Cathedral. His other work includes:

Giorgio Vasari includes a biography of Luca Signorelli in his Lives.