Lucerne is:
- in Switzerland:
- Lucerne (in German Luzern), capital of the Canton of Lucerne on Lake Lucerne (in German: Vierwaldstättersee).
- Lucerne (in German Luzern), capital of the Canton of Lucerne on Lake Lucerne (in German: Vierwaldstättersee).
- in the United States:
- Lucerne, Arkansas
- Lucerne, California
- Lucerne, Kings County
- Lucerne, Lake County
- Lucerne Valley, San Bernardino County
- Lucerne, Colorado
- Lucerne, Indiana
- Lucerne, Missouri (population 92 in 2000)
- Lucerne, Ohio
- Lucerne, Pennsylvania
- Lucerne, South Dakota
- Lucerne, Washington
- Lucerne, West Virginia
- Lucerne, Wyoming (population 525 in 2000)
- Lucerne Mines, Pennsylvania (population 951 in 2000)
- Lucerne Valley, California, in the Mojave Desert
- Lake Lucerne (disambiguation)
- Lake Lucerne, Florida (population 9'132 in 2000)
- Lake Lucerne, Georgia
- Lake Lucerne, Ohio
- Luzerne, Iowa (population 105 in 2000)
- Luzerne, New York
- Lake Luzerne-Hadley, New York
- Luzerne, Pennsylvania, a borough located in Luzerne County, Pennsylvania. In 2000, the borough had a total population of 2'952, the county 319'250.
- Luzerne Township, Pennsylvania is located in Fayette County, Pennsylvania (population in 2000: 4'683).