The Mark Twain Prize for American Humor is awarded by the John F. Kennedy Center for the Performing Arts annually since 1998. It is named after famous humorist Mark Twain.
- 1998 - Richard Pryor
- 1999 - Jonathan Winters
- 2000 - Carl Reiner
- 2001 - Whoopi Goldberg
- 2002 - Bob Newhart
- 2003 - Lily Tomlin
