The Max Planck Institute for the History of Science in Berlin was established in March 1994. Its research is primarily devoted to a theoretically oriented history of science, principally of the natural sciences, but with methodological perspectives drawn from the cognitive sciences and from cultural history. All three departments of the Institute aim at the construction of a 'historical epistemology' of the sciences.

Historical epistemology deals with the historical development of knowledge and the technical, social, intellectual, and cultural processes surrounding the acquisition of knowledge in context. Building upon detailed studies from the history of particular sciences, historical epistemology investigates the emergence and evolution of key concepts such as 'number', 'force', 'motion', 'gene', 'organism', and 'field', as well as central categories and practices like 'representation', 'probability', 'causality', 'experiment', 'deduction', 'determinism', and 'objectivity'. The combination of highly specific historical inquiries within this more global framework of inquiry permits comparisons and generalizations spanning numerous disciplines.

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