MCA can stand for:
- MCA (rapper) - A rapper in the group, The Beastie Boys
- MicroChannel architecture - a type of computer bus
- Music Corporation of America - a music booking company and record label.
- Master of Computer Applications - 3-years Professional Master's degree in Computer Science awarded in India
- Monochloroacetic Acid - Carboxylic acid, manufactured by chlorinating acetic acid. Systemic poisonous.
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