One Hundred and One Dalmatians is an animated film made by the Walt Disney Company in 1961, based on the novel The Hundred and One Dalmatians by Dodie Smith.

One Hundred and One Dalmatians features Rod Taylor as the voice of Pongo, the first of the dalmatians, and Betty Lou Gerson as the voice of the villainous Cruella De Vil. The plot centers around the fate of the kidnapped puppies of Pongo and Perdita.

One Hundred and One Dalmatians was remade in 1996 as 101 Dalmatians, a live-action film starring Glenn Close as Cruella De Vil (none of the animals talked in this version).

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