The abode of Bhagwan Sathya Sai. Situated in the Anantpur district of Andhra Pradesh, Puttaparthi draws thousands of devotees from all over the world. Puttaparthi houses Prashanthi Nilayam, the ashram of Baba. It is well connected by road, rail and air to the outer world. The newly opened railway station is called Sri Sathya Sai Prashanthi Nilayam.

Puttaparthi also has a charitable super speciality hospital.