Saint-Simon can refer to various people:
- Claude de Rouvroy, duc de Saint-Simon (1607-1693), French courtier
- Louis de Rouvroy, duc de Saint-Simon (1675-1755), French soldier, diplomatist and writer of memoirs
- Claude Henri de Rouvroy, Comte de Saint-Simon (1760-1825), the founder of French socialism
- Saint-Simon is a commune in the Charente département of France