The Tees-Exe line is an imaginary line that can be draw on a map of the British mainland which roughly divides the lowland and upland regions of the country.

The line links the mouth of the River Tees in Teesside, the north east of England with the mouth of the River Exe in Devon, the south west. The lowlands (sedimentary rocks) are predominant to the east of the line and higher land (igneous and metamorphic rocks) dominates to the west. As well as geology, those areas to the north and west of the line are wetter in climate than those to the east, although there are inevitably local variations.