Founded in 1984, the Whitehead Institute for Biomedical Research is a non-profit research and teaching institution located in Cambridge, Massachusetts. It is a quasi-autonomous division of the Massachusetts Institute of Technology, and its members and associate members hold faculty appointments in MIT's Biology Department.

The institute is one of the world's leading centers for genomic research. Its Center for Genome Research was active in the Human Genome Project, and reportedly contributed one-third of the human genome sequence announced in June 2000.

In June 2003, Eli and Edythe L. Broad pledged $100 million to build the Broad Institute, a joint venture of Whitehead, MIT, Harvard and local teaching hospitals. The new venture's mission is to expand tools for genomic medicine and apply them for the treatment of disease.

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