William Cavendish, 4th Duke of Devonshire (ca. 1720 - 1764), was a statesman and titular prime minister of Great Britain. He was First Lord of the Treasury from 1756 to 1757, in an administration effectively run by William Pitt the Elder. He married Lady Charlotte Boyle (1731 - 1754), the daughter and heiress of Richard Boyle, 4th Earl of Cork and 3rd Earl of Burlington, a famous architect and art collector. Through her, the Devonshires inherited Chiswick House, London; Burlington House; Bolton Abbey; Londesborough Hall, Yorkshire; Lismore Castle, County Waterford, Ireland.

Preceded by:
William Cavendish
Duke of Devonshire Followed by:
William Cavendish