MC Ren joined up with the ground breaking gangsta rap group N.W.A as he finished his senior year at Dominguiz High School in Compton. Clearly adding much hard-hitting vocals on the Straight Outta Compton (1988) album, soon found himself a much more valuable member of the group when Ice Cube departed in 1989.

After becoming the first hardcore rap group to gain mainstream success with Efil4zaggin reaching the number one spot on Billboard in 1991. Financial conflict between Dre and Ruthless Records lead to the group disbanding when Dr. Dre left to form Death Row Records. MC Ren released his debut E.P. with the help of Eazy-E in 1992, entitled Kizz My Black Azz. Surprisingly enough, with little commerical promotion, the album went gold. His next album, Life Sentence, was scrapped while converting to the Nation of Islam with guidance from his DJ, DJ Train. Shock of the Hour (1993) was put out the next year containing a few singles, none left any lasting impression.

MC Ren soon found hard times when DJ Train died in a house fire before the release of the ill-fated Villain in Black (1996). Before leaving Ruthless Records, Ren put out Ruthless For Life (1998) which proved a worthy comeback from his last album. As of 2002, Ren is working on another album; his lyrical abilities have been displayed with many guest appearances with artists from Ice Cube, Kurupt, Snoop Dog, Cypress Hill and many others.